A single dose of yellow fever vaccine is sufficient to confer sustained immunity and life-long protection against yellow fever disease. A booster dose of the vaccine is not needed. The vaccine provides effective immunity within 10 days for 80-100% of people vaccinated, and within 30 days for more than 99% of people vaccinated. Yellow fever vaccine-associated neurotropic disease. Age greater than 60 years and immunosuppression are risk factors for post-vaccinal encephalitis, also known as yellow fever vaccine-associated neurotropic disease (YEL-AND). (See ADVERSE REACTIONS section.) Almost all cases of YEL-AND have been in first-time vaccine recipients. Why get vaccinated? Yellow fever vaccine can prevent yellow fever. Yellow fever is a serious disease caused by the yellow fever virus. There is no medicine to treat or cure yellow fever. Yellow fever virus is spread by the bite of an infected mosquito. It is found in parts of Africa and South America. There is no cure – up to 50% of persons severely affected by yellow fever will die –but yellow fever can be prevented by a safe, affordable and highly effective vaccine. One injection offers full protection. mInImIZInG GlObAl rIsK Of OuTbreAKs, One VAccIne AT A TIme The Yellow Fever Initiative works to secure global vaccine supply and boost Designated Yellow Fever Vaccination Clinics International Hot Line for Yellow Fever 1-888-332-4559 CDC Travel Information YF Yellow Fever Vaccine Only---these offices will not be able to offer any travel vaccines except yellow fever vaccine O These offices can offer other travel vaccines in addition to the yellow fever vaccine S Required or mandatory vaccinations: Since 1988, the only internationally mandatory vaccine is the yellow fever vaccine. Another aspect that should be taken into account is the possible legal requirement of vaccination, established by some countries for the movement of travelers in their territory, such as, for example, the pilgrimage to Mecca xE6lh.

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